Selective inhibition of canonical STAT3 signaling suppresses K-ras mutant lung tumorigenesis and reinvigorates anti-tumor immunity.

doi:10.3389/fimmu.2025.1575181

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Article

Selective inhibition of canonical STAT3 signaling suppresses K-ras mutant lung tumorigenesis and reinvigorates anti-tumor immunity.

Frontiers in immunology - 1 Jan 2025

Clowers Michael J, Rahal Zahraa, Cho Sung-Nam, Krishna Avantika, Yuan Bo, Hamana Zorrilla Leticia G, Eckols T Kris, Kasembeli Moses M, Liu Samuel, Peng Stephen, Ramos-Castaneda Marco, Thompson Annamarie L, Rodriguez Reyna Carlos Ignacio, Larsen Katherine E, Grimaldo Maria T, Deng Shanshan, Karimi Nastaran, Chou Cody, Velasco Walter V, Zarghooni Melody, Alekseev Sayan, Solis Soto Luisa M, Ostrin Edwin J, Kadara Humam, Ekmekcioglu Suhendan, Tweardy David J, Moghaddam Seyed Javad

Abstract excerpt

Introduction: K-ras mutant lung adenocarcinoma (KM-LUAD) is a difficult-to-treat cancer subtype in which chronic inflammation pervades the tumor immune microenvironment (TIME). Pro-inflammatory pathways dampen the response to treatments, including immune checkpoint inhibitors, necessitating therapies that target this inflammatory signaling network in the TIME. One of the lynchpins of chronic inflammation in...

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Identifiers

PMID: 40356899
DOI: 10.3389/fimmu.2025.1575181
PMCID: PMC12066534

Genes

STAT3
CXCL9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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