GnT Motifs Can Increase T:A→G:C Mutation Rates Over 1000-fold in Bacteria.

Abstract excerpt

Nucleotides across a genome do not mutate at equal frequencies. Instead, specific nucleotide positions can exhibit much higher mutation rates than the genomic average due to their immediate nucleotide neighbors. These "mutational hotspots" can play a prominent role in adaptive evolution, yet we lack knowledge of which short nucleotide sequences drive hotspots. In this work, we employ a combination of experimental...

Topics

• Mutation Rate
• Nucleotide Motifs
• Pseudomonas fluorescens
• Salmonella
• Mutation
• Evolution, Molecular