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Article

On the mutational topology of the bacterial genome.

G3 (Bethesda, Md.) - 1 Mar 2013

Foster Patricia L, Hanson Andrew J, Lee Heewook, Popodi Ellen M, Tang Haixu

Abstract excerpt

By sequencing the genomes of 34 mutation accumulation lines of a mismatch-repair defective strain of Escherichia coli that had undergone a total of 12,750 generations, we identified 1625 spontaneous base-pair substitutions spread across the E. coli genome. These mutations are not distributed at random but, instead, fall into a wave-like spatial pattern that is repeated almost exactly in mirror image in the two...

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Share to DNA Replication
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23450823
DOI: 10.1534/g3.112.005355
PMCID: PMC3583449

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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