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Article

Membrane binding, internalization, and sorting of alpha-synuclein in the cell.

Acta neuropathologica communications - 14 Aug 2018

Masaracchia Caterina, Hnida Marilena, Gerhardt Ellen, Lopes da Fonseca Tomás, Villar-Pique Anna, Branco Tiago, Stahlberg Markus A, Dean Camin, Fernández Claudio O, Milosevic Ira, Outeiro Tiago F

Abstract excerpt

Alpha-synuclein (aSyn) plays a crucial role in Parkinson's disease (PD) and other synucleinopathies, since it misfolds and accumulates in typical proteinaceous inclusions. While the function of aSyn is thought to be related to vesicle binding and trafficking, the precise molecular mechanisms linking aSyn with synucleinopathies are still obscure. aSyn can spread in a prion-like manner between interconnected...

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Identifiers

PMID: 30107856
DOI: 10.1186/s40478-018-0578-1
PMCID: PMC6090819

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