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Article

Leveraging large-scale datasets and single cell omics data to develop a polygenic score for cisplatin-induced ototoxicity.

Human genomics - 8 Oct 2024

Miao Deanne Nixie R, Wilke MacKenzie A P, Pham John, Ladha Feryal, Singh Mansumeet, Arsenio Janilyn, Luca Emilia, Dabdoub Alain, Yang Wejian, Yang Jun J, Drögemöller Britt I

Abstract excerpt

BACKGROUND: Cisplatin-induced ototoxicity (CIO), characterized by irreversible and progressive bilateral hearing loss, is a prevalent adverse effect of cisplatin chemotherapy. Alongside clinical risk factors, genetic variants contribute to CIO and genome-wide association studies (GWAS) have highlighted the polygenicity of this adverse drug reaction. Polygenic scores (PGS), which integrate information from...

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PMID: 39380081
DOI: 10.1186/s40246-024-00679-5
PMCID: PMC11463131

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