Variants in WFS1 and Other Mendelian Deafness Genes Are Associated with Cisplatin-Associated Ototoxicity.

doi:10.1158/1078-0432.CCR-16-2809

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Variants in WFS1 and Other Mendelian Deafness Genes Are Associated with Cisplatin-Associated Ototoxicity.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jul 2017

Wheeler Heather E, Gamazon Eric R, Frisina Robert D, Perez-Cervantes Carlos, El Charif Omar, Mapes Brandon, Fossa Sophie D, Feldman Darren R, Hamilton Robert J, Vaughn David J, Beard Clair J, Fung Chunkit, Kollmannsberger Christian, Kim Jeri, Mushiroda Taisei, Kubo Michiaki, Ardeshir-Rouhani-Fard Shirin, Einhorn Lawrence H, Cox Nancy J, Dolan M Eileen, Travis Lois B

Abstract excerpt

Purpose: Cisplatin is one of the most commonly used chemotherapy drugs worldwide and one of the most ototoxic. We sought to identify genetic variants that modulate cisplatin-associated ototoxicity (CAO).Experimental Design: We performed a genome-wide association study (GWAS) of CAO using quantitative audiometry (4-12 kHz) in 511 testicular cancer survivors of European genetic ancestry. We performed polygenic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cisplatin

Share to Genome-Wide Association Study

Share to Genotype

Share to Hearing Loss

Share to Membrane Proteins

Share to Polymorphism, Single Nucleotide

Share to Testicular Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 28039263
DOI: 10.1158/1078-0432.CCR-16-2809
PMCID: PMC5493516

Genes

WFS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Variants in WFS1 and Other Mendelian Deafness Genes Are Associated with Cisplatin-Associated Ototoxicity.PMID 28039263Read ↗

Further Investigation of the Role of ACYP2 and WFS1 Pharmacogenomic Variants in the Development of Cisplatin-Induced Ototoxicity in Testicular Cancer Patients.Semantic proximity Read ↗

Association Between SLC16A5 Genetic Variation and Cisplatin-Induced Ototoxic Effects in Adult Patients With Testicular Cancer.Semantic proximity Read ↗

Leveraging large-scale datasets and single cell omics data to develop a polygenic score for cisplatin-induced ototoxicity.Semantic proximity Read ↗

Pharmacogenomics of cisplatin-induced ototoxicity.Semantic proximity Read ↗

Promoter region variation in NFE2L2 influences susceptibility to ototoxicity in patients exposed to high cumulative doses of cisplatin.Semantic proximity Read ↗

The association between DNA repair genes polymorphisms and cisplatin-induced ototoxicity in cancer patients: a systematic review.Semantic proximity Read ↗

Navigating the Genetic Risk of Chemotherapy-Induced Hearing Loss in the Stria Vascularis.Semantic proximity Read ↗

Clinical and Genome-Wide Analysis of Multiple Severe Cisplatin-Induced Neurotoxicities in Adult-Onset Cancer Survivors.Semantic proximity Read ↗

Genetic variation in Otos is associated with cisplatin-induced ototoxicity.Semantic proximity Read ↗

Genetic variants associated with cisplatin-induced ototoxicity.Semantic proximity Read ↗

Hearing genes and cisplatin deafness: a pilot study.Semantic proximity Read ↗

Impact of Population Pharmacogenomics on Cisplatin-Induced Neurotoxicities in Testicular Cancer Survivors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.