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Article

Clinical and Genome-Wide Analysis of Multiple Severe Cisplatin-Induced Neurotoxicities in Adult-Onset Cancer Survivors.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Dec 2020

Trendowski Matthew R, Wheeler Heather E, El-Charif Omar, Feldman Darren R, Hamilton Robert J, Vaughn David J, Fung Chunkit, Kollmannsberger Christian, Einhorn Lawrence H, Travis Lois B, Dolan M Eileen

Abstract excerpt

PURPOSE: Cisplatin is a first-line chemotherapeutic for many cancers, but causes neurotoxicity including hearing loss, tinnitus, and peripheral sensory neuropathy. However, no study has comprehensively characterized risk factors for developing multiple (>1) severe neurotoxicities. EXPERIMENTAL DESIGN: The relationship between multiple severe neurotoxicities and age, cumulative cisplatin dose, medical history, and...

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Identifiers

PMID: 32998964
DOI: 10.1158/1078-0432.CCR-20-2682
PMCID: PMC7744329

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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