Association Between SLC16A5 Genetic Variation and Cisplatin-Induced Ototoxic Effects in Adult Patients With Testicular Cancer.

doi:10.1001/jamaoncol.2017.0502

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Article

Association Between SLC16A5 Genetic Variation and Cisplatin-Induced Ototoxic Effects in Adult Patients With Testicular Cancer.

JAMA oncology - 1 Nov 2017

Drögemöller Britt I, Monzon Jose G, Bhavsar Amit P, Borrie Adrienne E, Brooks Beth, Wright Galen E B, Liu Geoffrey, Renouf Daniel J, Kollmannsberger Christian K, Bedard Philippe L, Aminkeng Folefac, Amstutz Ursula, Hildebrand Claudette A, Gunaretnam Erandika P, Critchley Carol, Chen Zhuo, Brunham Liam R, Hayden Michael R, Ross Colin J D, Gelmon Karen A, Carleton Bruce C

Abstract excerpt

IMPORTANCE: Cisplatin-induced ototoxic effects are an important complication that affects testicular cancer survivors as a consequence of treatment. The identification of genetic variants associated with this adverse drug reaction will further our mechanistic understanding of its development and potentially lead to strategies to prevent ototoxic effects. OBJECTIVE: To identify the genetic variants associated with...

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PMID: 28448657
DOI: 10.1001/jamaoncol.2017.0502
PMCID: PMC5824214

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