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Article

Navigating the Genetic Risk of Chemotherapy-Induced Hearing Loss in the Stria Vascularis.

Clinical pharmacology and therapeutics - 1 Apr 2026

Lazetic Tara, Miao Deanne Nixie R, Drögemöller Britt I, Dabdoub Alain, Abitbol Julia M

Abstract excerpt

Cisplatin is a chemotherapy drug that causes permanent hearing loss by damaging a critical tissue lining the inner ear, called the stria vascularis (SV). Currently, the molecular mechanisms of SV damage are largely unknown and the incidence of ototoxicity in patients cannot be reliably predicted. Growing evidence suggests certain genetic variants expressed in the SV are significant risk factors for ototoxicity,...

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Identifiers

PMID: 41346314
DOI: 10.1002/cpt.70160
PMCID: PMC12997515

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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