Article

Otoprotection in Children Treated for Cancer: A CODEPEH Review Using PRISMA Methodology on Pharmacological Agents, Biomarkers and Genetic Susceptibility

2026-08-03

Abstract excerpt

Ototoxicity associated with platinum compounds, especially cisplatin, remains one of the most important sequelae of paediatric cancer treatment because it is common, permanent, bilateral and disproportionately affects language, learning, neurodevelopment and quality of life. This review synthesises evidence on pharmacological prevention, early detection through audiological monitoring, biomarkers and genetic risk...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 326256ce-7668-583d-abd2-300baeae2204
DOI: 10.20944/preprints202608.0032.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Otoprotection in Children Treated for Cancer: A CODEPEH Review Using PRISMA Methodology on Pharmacological Agents, Biomarkers and Genetic SusceptibilityDOI 10.20944/preprints202608.0032.v1Read

Ototoxicity and cancer therapy.Semantic proximity Read

Usefulness of current candidate genetic markers to identify childhood cancer patients at risk for platinum-induced ototoxicity: Results of the European PanCareLIFE cohort study.Semantic proximity Read

Genetic markers of cisplatin-induced hearing loss in children.Semantic proximity Read

Pharmacogenomics of cisplatin-induced ototoxicity.Semantic proximity Read

Genetic variation of cisplatin-induced ototoxicity in non-cranial-irradiated pediatric patients using a candidate gene approach: The International PanCareLIFE Study.Semantic proximity Read

Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.Semantic proximity Read

Clinical and genetic associations for carboplatin-related ototoxicity in children treated for retinoblastoma: A retrospective noncomparative single-institute experience.Semantic proximity Read

TPMT, COMT and ACYP2 genetic variants in paediatric cancer patients with cisplatin-induced ototoxicity.Semantic proximity Read

Genetic variants associated with cisplatin-induced ototoxicity.Semantic proximity Read

TCERG1L allelic variation is associated with cisplatin-induced hearing loss in childhood cancer, a PanCareLIFE studySemantic proximity Read

Challenges in interpreting the evidence for genetic predictors of ototoxicity.Semantic proximity Read

Systematic Review and Meta-Analysis of the Influence of Genetic Variation on Ototoxicity in Platinum-Based Chemotherapy.Semantic proximity Read