Article
Further Investigation of the Role of ACYP2 and WFS1 Pharmacogenomic Variants in the Development of Cisplatin-Induced Ototoxicity in Testicular Cancer Patients.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Apr 2018
Drögemöller Britt I, Brooks Beth, Critchley Carol, Monzon José G, Wright Galen E B, Liu Geoffrey, Renouf Daniel J, Kollmannsberger Christian K, Bedard Philippe L, Hayden Michael R, Gelmon Karen A, Carleton Bruce C, Ross Colin J D
Abstract excerpt
Purpose: Adverse drug reactions such as ototoxicity, which occurs in approximately one-fifth of adult patients who receive cisplatin treatment, can incur large socioeconomic burdens on patients with testicular cancer who develop this cancer during early adulthood. Recent genome-wide association studies have identified genetic variants in ACYP2 and WFS1 that are associated with cisplatin-induced ototoxicity. We...
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