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Article

Machine learning model identifies genetic predictors of cisplatin-induced ototoxicity in CERS6 and TLR4.

Computers in biology and medicine - 1 Dec 2024

Arab Ali, Kashani Bahareh, Cordova-Delgado Miguel, Scott Erika N, Alemi Kaveh, Trueman Jessica, Groeneweg Gabriella, Chang Wan-Chun, Loucks Catrina M, Ross Colin J D, Carleton Bruce C, Ester Martin

Abstract excerpt

BACKGROUND: Cisplatin-induced ototoxicity remains a significant concern in pediatric cancer treatment due to its permanent impact on quality of life. Previously, genetic association analyses have been performed to detect genetic variants associated with this adverse reaction. METHODS: In this study, a combination of interpretable neural networks and Generative Adversarial Networks (GANs) was employed to identify...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 39488053
DOI: 10.1016/j.compbiomed.2024.109324

Genes

TLR4
CERS6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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