Article

Dynamic interplay of polygenic risk across brain disorders, neuropathological endophenotypes, and neuropsychiatric symptoms

2026-07-02

Abstract excerpt

Neurodegenerative and psychiatric brain disorders show substantial heterogeneity in clinical and neuropathological manifestations, possibly reflecting both distinct and shared pathogenic mechanisms. Our understanding of brain disorder heterogeneity is limited by the scarcity of deeply phenotyped, multi-modal post-mortem brain bank cohorts. Here, we integrated genotype, clinical and neuropathological data from 2,55...

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Literature Corpus work: c69a7a3a-cb44-5c97-9449-1fa791ea2b5f
DOI: 10.64898/2026.06.30.26356924

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