Article
Exploiting phenotypic heterogeneity to improve production of glutathione by yeast.
Microbial cell factories - 7 Oct 2024
Xu Mingzhi, Vallières Cindy, Finnis Chris, Winzer Klaus, Avery Simon V
Abstract excerpt
BACKGROUND: Gene expression noise (variation in gene expression among individual cells of a genetically uniform cell population) can result in heterogenous metabolite production by industrial microorganisms, with cultures containing both low- and high-producing cells. The presence of low-producing individuals may be a factor limiting the potential for high yields. This study tested the hypothesis that...
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