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Article

Laboratory evolution of glutathione biosynthesis reveals natural compensatory pathways.

Nature chemical biology - 1 Feb 2011

Veeravalli Karthik, Boyd Dana, Iverson Brent L, Beckwith Jon, Georgiou George

Abstract excerpt

The first and highly conserved step in glutathione (GSH) biosynthesis is formation of γ-glutamyl cysteine by the enzyme glutamate-cysteine ligase (GshA). However, bioinformatic analysis revealed that many prokaryotic species that encode GSH-dependent proteins lack the gene for this enzyme. To understand how bacteria cope without gshA, we isolated Escherichia coli ΔgshA multigenic suppressors that accumulated...

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Identifiers

PMID: 21186348
DOI: 10.1038/nchembio.499
PMCID: PMC4129951

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