Article
An internal deletion in MTH1 enables growth on glucose of pyruvate-decarboxylase negative, non-fermentative Saccharomyces cerevisiae.
Microbial cell factories - 15 Sept 2012
Oud Bart, Flores Carmen-Lisset, Gancedo Carlos, Zhang Xiuying, Trueheart Joshua, Daran Jean-Marc, Pronk Jack T, van Maris Antonius J A
Abstract excerpt
BACKGROUND: Pyruvate-decarboxylase negative (Pdc⁻) strains of Saccharomyces cerevisiae combine the robustness and high glycolytic capacity of this yeast with the absence of alcoholic fermentation. This makes Pdc⁻S. cerevisiae an interesting platform for efficient conversion of glucose towards pyruvate-derived products without formation of ethanol as a by-product. However, Pdc⁻ strains cannot grow on high glucose...
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