Preparation of a γ-glutamylcysteine-enriched yeast extract from a newly developed GSH2-deficient strain.

doi:10.1016/j.jbiosc.2012.08.009

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Article

Preparation of a γ-glutamylcysteine-enriched yeast extract from a newly developed GSH2-deficient strain.

Journal of bioscience and bioengineering - 1 Jan 2013

Nishiuchi Hiroaki, Suehiro Mariko, Sugimoto Reiko, Yamagishi Kazuo

Abstract excerpt

Gamma-glutamylcysteine (γ-GC), the precursor of glutathione (GSH), may have significant health benefits as a dietary supplement, but there are few cost-effective methods available for its large-scale production. We developed an efficient method for producing γ-GC in a mutant yeast strain using a three-step breeding procedure and a unique cultivation process. In the first breeding step, we prepared a glutathione...

Topics

Cell Fractionation
Chemical Fractionation
Culture Media
Dipeptides
F-Box Proteins
Functional Food
Glutathione
Glutathione Synthase
Mutation
Pantothenic Acid
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Selenic Acid
Ubiquitin-Protein Ligase Complexes

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Identifiers

PMID: 22986308
DOI: 10.1016/j.jbiosc.2012.08.009

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