Synthetic rescue couples NADPH generation to metabolite overproduction in Saccharomyces cerevisiae.

doi:10.1016/j.ymben.2017.08.004

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Article

Synthetic rescue couples NADPH generation to metabolite overproduction in Saccharomyces cerevisiae.

Metabolic engineering - 1 Sept 2017

Partow Siavash, Hyland Patrick B, Mahadevan Radhakrishnan

Abstract excerpt

Engineering the redox cofactor metabolism is known to be a key challenge in developing a platform strain for biosynthesis of valuable products. Hence, general strategies for manipulation of co-factor metabolism in industrially relevant hosts are of significance. Here, we demonstrate an improvement in α-ketoglutarate (AKG) production in S. cerevisiae using a novel approach based on synthetic rescue. Here, we first...

Topics

Ketoglutaric Acids
Mutation
NADP
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins

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Open in PubMed

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PMID: 28803913
DOI: 10.1016/j.ymben.2017.08.004

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