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Article

Force-mediated recruitment and reprogramming of healthy endothelial cells drive vascular lesion growth.

Nature communications - 6 Oct 2024

Shapeti Apeksha, Barrasa-Fano Jorge, Abdel Fattah Abdel Rahman, de Jong Janne, Sanz-Herrera José Antonio, Pezet Mylène, Assou Said, de Vet Emilie, Elahi Seyed Ali, Ranga Adrian, Faurobert Eva, Van Oosterwyck Hans

Abstract excerpt

Force-driven cellular interactions are crucial for cancer cell invasion but remain underexplored in vascular abnormalities. Cerebral cavernous malformations (CCM), a vascular abnormality characterized by leaky vessels, involves CCM mutant cells recruiting wild-type endothelial cells to form and expand mosaic lesions. The mechanisms behind this recruitment remain poorly understood. Here, we use an in-vitro model...

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Identifiers

PMID: 39370485
DOI: 10.1038/s41467-024-52866-6
PMCID: PMC11456588

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