Article

Force-mediated recruitment and reprogramming of healthy endothelial cells drive vascular lesion growth

2023-11-27

Abstract excerpt

Force-driven cellular interactions are known to play a critical role in cancer cell invasion, but have remained largely unexplored in the context of vascular abnormalities, partly due to a lack of suitable genetic and cellular models. One such vascular abnormality, cerebral cavernous malformation (CCM) is characterized by leaky, tumor-like vessels in the brain, where CCM mutant cells recruit wild-type cells from t...

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Literature Corpus work: 485a5b5e-1c52-5d71-8757-b7cd617127d1
DOI: 10.1101/2023.11.27.568780

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