Article

Cerebral Cavernous Malformations Develop through Clonal Expansion of Mutant Endothelial Cells

2018-08-31

Abstract excerpt

<h4>Rationale</h4> Vascular malformations arise in vessels throughout the entire body. Causative genetic mutations have been identified for many of these diseases; however, little is known about the mutant cell lineage within these malformations. <h4>Objective</h4> We utilize an inducible mouse model of cerebral cavernous malformations (CCMs) coupled with a multi-color fluorescent reporter to visualize the contr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 195cbf5b-f41f-5b27-b2ab-1a744fada57b
DOI: 10.1101/405191

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cerebral Cavernous Malformations Develop through Clonal Expansion of Mutant Endothelial CellsDOI 10.1101/405191Read

Cerebral Cavernous Malformations Develop Through Clonal Expansion of Mutant Endothelial CellsSemantic proximity Read

Endothelial cell clonal expansion in the development of cerebral cavernous malformationsSemantic proximity Read

Loss of cerebral cavernous malformation 3 (Ccm3) in neuroglia leads to CCM and vascular pathology.Semantic proximity Read

Mapping endothelial-cell diversity in cerebral cavernous malformations at single-cell resolution.Semantic proximity Read

Developmental timing of CCM2 loss influences cerebral cavernous malformations in miceSemantic proximity Read

Cerebral Cavernous Malformation Pathogenesis: Investigating Lesion Formation and Progression with Animal Models.Semantic proximity Read

Cerebral cavernous malformation development in chronic mouse models driven by dual recombinases induced gene deletion in brain endothelial cellsSemantic proximity Read

Tissue-specific conditional CCM2 knockout mice establish the essential role of endothelial CCM2 in angiogenesis: implications for human cerebral cavernous malformations.Semantic proximity Read

ccm1 cell autonomously regulates endothelial cellular morphogenesis and vascular tubulogenesis in zebrafish.Semantic proximity Read

Neuroinflammation plays a critical role in cerebral cavernous malformation diseaseSemantic proximity Read

Lack of CCM1 induces hypersprouting and impairs response to flowSemantic proximity Read

Postzygotic mosaicism in cerebral cavernous malformationSemantic proximity Read