Article

Semaphorin 3A and 3F overexpression in TIE2 hyperactive endothelial cells contribute to the pathological lumen expansion in venous malformation

2025-07-20

Abstract excerpt

<h4>Abstract (formatted)</h4> <h4>Background</h4> Venous malformation (VM) are developmental defects of the vasculature characterized by tremendously enlarged and dysfunctional veins. Gain-of-function somatic mutations in the endothelial-specific tyrosine kinase receptor TIE2 have been identified as leading driver of VM pathogenesis. The aim of this study was to determine whether the aberrant venous lumen expans...

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Literature Corpus work: 68bfc61f-6d62-5b0d-a6ba-dad74cc4bf46
DOI: 10.1101/2025.07.18.665640

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