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Article

Cerebral Cavernous Malformations Develop Through Clonal Expansion of Mutant Endothelial Cells

25 Oct 2018

Abstract excerpt

RATIONALE: Vascular malformations arise in vessels throughout the entire body. Causative genetic mutations have been identified for many of these diseases; however, little is known about the mutant cell lineage within these malformations. OBJECTIVE: We utilize an inducible mouse model of cerebral cavernous malformations (CCMs) coupled with a multicolor fluorescent reporter to visualize the contribution of mutant...

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PMID: 30359189
DOI: 10.1161/circresaha.118.313970

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