Article

Hyaluronic acid turnover controls the severity of Cerebral Cavernous Malformations in bioengineered human micro-vessels

2023-03-29

Abstract excerpt

<h4>ABSTRACT</h4> Cerebral Cavernous Malformations (CCMs) are vascular lesions that predominantly form in blood vessels of the central nervous system (CNS) upon loss of the CCM multimeric protein complex. The endothelial cells (ECs) within CCM lesions are characterised by overactive MEKK3 kinase and KLF2/4 transcription factor signalling, leading to pathological changes such as increased EC spreading and reduced...

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Literature Corpus work: 8942e131-96c3-5ca6-91f7-28a3609353a6
DOI: 10.1101/2023.03.27.534302

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