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Highly sensitive and accurate detection of ALK-TKI resistance mutations by oligoribonucleotide interference-PCR (ORNi-PCR)-based methods.

Lung cancer (Amsterdam, Netherlands) - 1 Nov 2024

Tabe Chiori, Fujita Toshitsugu, Taima Kageaki, Tanaka Hisashi, Makiguchi Tomonori, Itoga Masamichi, Ishioka Yoshiko, Tasaka Sadatomo, Fujii Hodaka

Abstract excerpt

BACKGROUND: Patients with anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC) are treated with ALK tyrosine kinase inhibitors (TKIs). Although most patients benefit from ALK-TKIs, the development of resistance mutations is common and results in NSCLC recurrence. To identify ALK-TKI-resistant NSCLC at the early recurrent phase, highly sensitive and accurate methods for the detection of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39369610
DOI: 10.1016/j.lungcan.2024.107969

Genes

ALK

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