Article
Picoliter-Droplet Digital Polymerase Chain Reaction-Based Analysis of Cell-Free Plasma DNA to Assess EGFR Mutations in Lung Adenocarcinoma That Confer Resistance to Tyrosine-Kinase Inhibitors.
The oncologist - 1 Feb 2016
Seki Yoshitaka, Fujiwara Yutaka, Kohno Takashi, Takai Erina, Sunami Kuniko, Goto Yasushi, Horinouchi Hidehito, Kanda Shintaro, Nokihara Hiroshi, Watanabe Shun-ichi, Ichikawa Hitoshi, Yamamoto Noboru, Kuwano Kazuyoshi, Ohe Yuichiro
Abstract excerpt
PURPOSE: The objective of this study was to evaluate the utility of analyzing cell-free plasma DNA (cfDNA) by picoliter-droplet digital polymerase chain reaction (ddPCR) to detect EGFR mutations that confer resistance to tyrosine-kinase inhibitors (TKIs) used for treatment of lung adenocarcinoma (LADC). EXPERIMENTAL DESIGN: Thirty-five LADC patients who received epidermal growth factor receptor (EGFR)-TKI...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.