Article
Establishment and validation of a novel droplet digital PCR assay for ultrasensitive detection and dynamic monitoring of EGFR mutations in peripheral blood samples of non-small-cell lung cancer patients.
Clinica chimica acta; international journal of clinical chemistry - 1 Nov 2020
Tang Chuanhao, Zhu Lingxiang, Zhang Lijuan, Tan Chianru, Peng Zhiyong, Liu Baoxia, Liu Wenjing, Hu Haixu, Bai Yu, Wang Bo, Lin Li, Liang Jun, Li Xiaoyan, Guo Yong, Liu Yi
Abstract excerpt
BACKGROUND: Droplet digital PCR (ddPCR)-based blood detection of EGFR mutations plays significant roles in the individualized therapy of non-small-cell lung cancer (NSCLC) patients. However, a standard assay that is approved by health authorities is still lacking. Additionally, the proper application of this method in clinical settings also needs further investigation. METHODS: The performance of a newly...
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