Article
Multiplex picoliter-droplet digital PCR for quantitative assessment of EGFR mutations in circulating cell-free DNA derived from advanced non-small cell lung cancer patients.
Molecular medicine reports - 1 Aug 2017
Yu Qian, Huang Fei, Zhang Meilin, Ji Haiying, Wu Shenchao, Zhao Ying, Zhang Chunyan, Wu Jiong, Wang Beili, Pan Baisheng, Zhang Xin, Guo Wei
Abstract excerpt
To explore the possible diagnostic value of liquid biopsy, two multiplex panels using picoliter-droplet digital polymerase chain reaction (ddPCR) were established to quantitatively assess the epidermal growth factor receptor (EGFR) mutations in cell‑free DNA (cfDNA) extracted from the plasma of advanced non‑small cell lung cancer (NSCLC) patients. Plasma samples derived from 22 patients with stage IIIB/IV NSCLC...
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