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Article

Therapy Monitoring of EGFR-Positive Non-Small-Cell Lung Cancer Patients Using ddPCR Multiplex Assays.

The Journal of molecular diagnostics : JMD - 1 Apr 2021

de Kock Remco, van den Borne Ben, Youssef-El Soud Maggy, Belderbos Huub, Brunsveld Luc, Scharnhorst Volkher, Deiman Birgit

Abstract excerpt

The detection of EGFR-sensitizing and EGFR-resistance mutations in advanced non-small-cell lung cancer patients is important for the selection and monitoring of EGFR tyrosine-kinase inhibitor therapy. Droplet digital PCR (ddPCR) multiplex assays allow for sensitive and simultaneous detection of multiple mutations in cell-free DNA (cfDNA) with a minimum of extract needed and at lower cost. Patients were screened...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33486072
DOI: 10.1016/j.jmoldx.2021.01.003

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