Article
Detection of EGFR T790M mutation using liquid biopsy for non-small cell lung cancer: Utility of droplet digital polymerase chain reaction vs. cobas real-time polymerase chain reaction.
Pathology, research and practice - 1 Mar 2024
Zungsontiporn Nicha, Ouwongprayoon Pongsakorn, Boonsirikamchai Piyaporn, Leelayuwatanakul Nophol, Vinayanuwattikun Chanida, Moonai Kantika, Khongkhaduead Ekkachai, Thorner Paul Scott, Shuangshoti Shanop, Teerapakpinyo Chinachote
Abstract excerpt
BACKGROUND: Digital platforms for mutation detection yield higher sensitivity than non-digital platforms but lack universal positive cut-off values that correlate with the outcome of osimertinib treatment. This study determined compared droplet digital polymerase chain reaction (ddPCR) to the standard cobas assay for epithelial growth factor receptor (EGFR) T790M mutation detection in patients with non-small cell...
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