Article
Ultra-Sensitive Detection of the Pretreatment EGFR T790M Mutation in Non-Small Cell Lung Cancer Patients with an EGFR-Activating Mutation Using Droplet Digital PCR.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 2015
Watanabe Masaru, Kawaguchi Tomoya, Isa Shun-ichi, Ando Masahiko, Tamiya Akihiro, Kubo Akihito, Saka Hideo, Takeo Sadanori, Adachi Hirofumi, Tagawa Tsutomu, Kakegawa Seiichi, Yamashita Motohiro, Kataoka Kazuhiko, Ichinose Yukito, Takeuchi Yukiyasu, Sakamoto Kazuhiro, Matsumura Akihide, Koh Yasuhiro
Abstract excerpt
PURPOSE: The resistance to the EGFR tyrosine kinase inhibitors (TKI) is a major concern in non-small cell lung cancer (NSCLC) treatment. T790M mutation in EGFR accounts for nearly 50% of the acquired resistance to EGFR-TKIs. Earlier studies suggested that T790M mutation was also detected in TKI-naïve NSCLCs in a small cohort. Here, we use an ultra-sensitive droplet digital PCR (ddPCR) technique to address the...
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