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Digital PCR detection of EGFR somatic mutations in non-small-cell lung cancer formalin fixed paraffin embedded samples.

Molecular and cellular probes - 1 Aug 2021

Carvalho Tamyres Mingorance, Dourado Renata Montoro, Nakatani Sueli Massumi, Barros Duarte Cesar Augusto, Ioshii Sergio Ossamu, Riediger Irina Nastassja, Tuon Felipe Francisco, Winter Boldt Angelica Beate

Abstract excerpt

BACKGROUND: Digital PCR (dPCR) is proposed to replace real time PCR and Sanger sequencing for detection and quantification of rare mutations, frequently unnoticed in the mass of tumoral cells. Screening of endothelial growth factor receptor (EGFR) mutations is mandatory before treatment with EGFR-targeted therapy with small-molecule tyrosine kinase inhibitors, which has been approved for the treatment of advanced...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34089806
DOI: 10.1016/j.mcp.2021.101745

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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