Article
Enzymatic Plasticity Inspired by the Diterpene Cyclase CotB2.
ACS chemical biology - 16 Oct 2020
Tang Xiaowen, Zhang Fan, Zeng Tao, Li Wei, Yin Sheng, Wu Ruibo
Abstract excerpt
Enzymatic plasticity, as a modern term referring to the functional conversion of an enzyme, is significant for enzymatic activity redesign. The bacterial diterpene cyclase CotB2 is a typical plastic enzyme by which its native form precisely conducts a chemical reaction while its mutants diversify the catalytic functions drastically. Many efforts have been made to disclose the mysteries of CotB2 enzyme catalysis....
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