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Article

LRP1 Repression by SNAIL Results in ECM Remodeling in Genetic Risk for Vascular Diseases.

Circulation research - 8 Nov 2024

Liu Lu, Henry Joséphine, Liu Yingwei, Jouve Charlène, Hulot Jean-Sébastien, Georges Adrien, Bouatia-Naji Nabila

Abstract excerpt

BACKGROUND: Genome-wide association studies implicate common genetic variations in the LRP1 (low-density lipoprotein receptor-related protein 1 gene) locus at risk for multiple vascular diseases and traits. However, the underlying biological mechanisms are unknown. METHODS: Fine mapping analyses included Bayesian colocalization to identify the most likely causal variant. Human induced pluripotent stem cells were...

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Identifiers

PMID: 39355906
DOI: 10.1161/CIRCRESAHA.124.325269
PMCID: PMC11542979

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