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Regulatory mechanisms in multiple vascular diseases locus <i>LRP1</i> involve repression by SNAIL and extracellular matrix remodeling

2023-05-09

Abstract excerpt

<h4>Background</h4> Genome-wide association studies (GWAS) implicate common genetic variations in the low-density lipoprotein receptor-related protein 1 locus (LRP1) in risk for multiple vascular diseases and traits. However, the underlying biological mechanisms are unknown. <h4>Methods</h4> Fine mapping analyses included Bayesian colocalization to identify the most likely causal variant. Human induced pluripo...

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Literature Corpus work
41f7beac-b8a3-5be2-b83d-ca255b8502e6
DOI
10.1101/2023.05.09.539992
Open publication

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Regulatory mechanisms in multiple vascular diseases locus <i>LRP1</i> involve repression by SNAIL and extracellular matrix remodelingDOI 10.1101/2023.05.09.539992
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