Patterns of cortical thickness according to APOE genotype in Alzheimer's disease.

doi:10.1159/000258100

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Article

Patterns of cortical thickness according to APOE genotype in Alzheimer's disease.

Dementia and geriatric cognitive disorders - 1 Jan 2009

Gutiérrez-Galve Leticia, Lehmann Manja, Hobbs Nicola Z, Clarkson Matthew J, Ridgway Gerard R, Crutch Sebastian, Ourselin Sebastien, Schott Jonathan M, Fox Nick C, Barnes Josephine

Abstract excerpt

BACKGROUND: Possession of one or more apolipoprotein E (APOE) epsilon4 alleles may influence the distribution of atrophy and clinical phenotype. We aimed to assess the influence of APOE genotype on cortical thickness and regional brain volumes in AD (Alzheimer's disease). METHODS: We included 38 patients (9 epsilon4 non-carriers, 23 epsilon4 heterozygotes, 6 epsilon4 homozygotes) and 23 controls. Each subject had...

Topics

Aged
Alzheimer Disease
Apolipoprotein E4
Atrophy
Cerebral Cortex
Cognition Disorders
Female
Genotype
Gyrus Cinguli
Hippocampus
Humans
Magnetic Resonance Imaging
Male
Middle Aged

Source

Open in PubMed

Identifiers

PMID: 19940480
DOI: 10.1159/000258100

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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