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Cellular senescence, p21, and the path to fibrosis

30 Sept 2024

Abstract excerpt

Senescent cells secrete bioreactive molecules that promote disease, fibrosis, and aging, yet the molecular mechanisms driving the production of these secreted factors remain incompletely understood. In this issue, Papismadov et al (2024) report that p21 (CDKN1A), known to activate the senescence growth arrest, also regulates expression of extracellular matrix components that promote fibrosis, thereby revealing...

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PMID: 39349843
DOI: 10.1038/s44318-024-00245-8

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