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Article

Deciphering the possible role of MmpL7 efflux pump in SQ109 resistance in Mycobacterium tuberculosis.

Annals of clinical microbiology and antimicrobials - 28 Sept 2024

Jing Wei, Zhang Fuzhen, Shang Yuanyuan, Shi Wenhui, Yao Cong, Zhang Xuxia, Chu Naihui, Lu Jie, Yuan Jinfeng

Abstract excerpt

BACKGROUND: SQ109 is a promising candidate drug for the treatment of patients with drug-resistant tuberculosis (DR-TB). The purpose of this study was to investigate the activity of SQ109 against clinical isolates of Mycobacterium tuberculosis (MTB) from patients with multidrug-resistant TB (MDR-TB) and pre-extensively drug-resistant TB (pre-XDR-TB), and to explore new drug-resistant mechanisms of SQ109. METHODS:...

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Identifiers

PMID: 39342331
DOI: 10.1186/s12941-024-00746-8
PMCID: PMC11439249

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