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HC2091 Kills Mycobacterium tuberculosis by Targeting the MmpL3 Mycolic Acid Transporter

13 Apr 2018

Abstract excerpt

ABSTRACT Tuberculosis, caused by the intracellular pathogen Mycobacterium tuberculosis , is a deadly disease that requires a long course of treatment. The emergence of drug-resistant strains has driven efforts to discover new small molecules that can kill the bacterium. Here, we report characterizations of the compound HC2091, which kills M. tuberculosis in a time- and dose-dependent manner in vitro and inhibits...

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PMID: 29661875
DOI: 10.1128/aac.02459-17

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