Article

S288T mutation altering MmpL3 periplasmic domain channel and H-bond network: A novel dual drug resistance mechanism

2023-09-25

Abstract excerpt

Mycobacterial membrane proteins Large 3 (MmpL3) is responsible for the transport of mycobacterial acids out of cell membrane to form cell wall, which is essential for the survival of Mycobacterium tuberculosis ( Mtb ) and has become a potent anti-tuberculosis target. Drug resistance has always been the bottleneck problem in clinical treatment of tuberculosis. The S288T mutant of MmpL3 shows significant resistance...

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Literature Corpus work: 6e89b791-59b6-5d37-8b82-2a883c0e8fa6
DOI: 10.21203/rs.3.rs-3354672/v1

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