Article

Hydroxylation of antitubercular drug candidate, SQ109, by mycobacterial cytochrome P450

2020-08-27

Abstract excerpt

Spreading of the multidrug-resistant (MDR) strains of the deadliest pathogen Mycobacterium tuberculosis (Mtb) generates the need for new effective drugs. SQ109 showed activity against resistant Mtb and already advanced to Phase II/III clinical trials. Fast SQ109 degradation is attributed to the human liver Cytochrome P450s (CYPs). However, no information is available about interactions of the drug with Mtb CYPs....

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Literature Corpus work: ee9727d2-b683-55ad-9d27-477a8133c29a
DOI: 10.1101/2020.08.27.269936

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