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Article

Role of the Cys154Arg Substitution in Ribosomal Protein L3 in Oxazolidinone Resistance in Mycobacterium tuberculosis.

Antimicrobial agents and chemotherapy - 1 May 2016

Makafe Gaëlle Guiewi, Cao Yuanyuan, Tan Yaoju, Julius Mugweru, Liu Zhiyong, Wang Changwei, Njire Moses M, Cai Xingshan, Liu Tianzhou, Wang Bangxing, Pang Wei, Tan Shouyong, Zhang Buchang, Yew Wing Wai, Lamichhane Gyanu, Guo Jintao, Zhang Tianyu

Abstract excerpt

We expressed the wild-type rplC and mutated rplC (Cys154Arg) genes, respectively, in Mycobacterium tuberculosis H37Ra and H37Rv in an attempt to delineate the role of rplC (Cys154Arg) regarding oxazolidinone resistance. An increase of the MICs of linezolid (LZD) and sutezolid (PNU-100480, PNU) against the recombinant mycobacteria with overexpressed rplC mutation (Cys154Arg) was found, suggesting the rplC gene is...

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Identifiers

PMID: 26953211
DOI: 10.1128/AAC.00152-16
PMCID: PMC4862453

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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