Article
SQ109 targets MmpL3, a membrane transporter of trehalose monomycolate involved in mycolic acid donation to the cell wall core of Mycobacterium tuberculosis.
Antimicrobial agents and chemotherapy - 1 Apr 2012
Tahlan Kapil, Wilson Regina, Kastrinsky David B, Arora Kriti, Nair Vinod, Fischer Elizabeth, Barnes S Whitney, Walker John R, Alland David, Barry Clifton E, Boshoff Helena I
Abstract excerpt
SQ109, a 1,2-diamine related to ethambutol, is currently in clinical trials for the treatment of tuberculosis, but its mode of action remains unclear. Here, we demonstrate that SQ109 disrupts cell wall assembly, as evidenced by macromolecular incorporation assays and ultrastructural analyses. SQ109 interferes with the assembly of mycolic acids into the cell wall core of Mycobacterium tuberculosis, as bacilli...
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