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Article

MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212.

Antimicrobial agents and chemotherapy - 1 Jan 2012

La Rosa Valentina, Poce Giovanna, Canseco Julio Ortiz, Buroni Silvia, Pasca Maria Rosalia, Biava Mariangela, Raju Ravikiran M, Porretta Giulio Cesare, Alfonso Salvatore, Battilocchio Claudio, Javid Babak, Sorrentino Flavia, Ioerger Thomas R, Sacchettini James C, Manetti Fabrizio, Botta Maurizio, De Logu Alessandro, Rubin Eric J, De Rossi Edda

Abstract excerpt

The 1,5-diarylpyrrole derivative BM212 was previously shown to be active against multidrug-resistant clinical isolates and Mycobacterium tuberculosis residing within macrophages as well as against Mycobacterium avium and other atypical mycobacteria. To determine its mechanism of action, we identi...

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Identifiers

PMID: 22024828
DOI: 10.1128/AAC.05270-11
PMCID: PMC3256021

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22024828-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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