Article
Multiple Mutations in Mycobacterium tuberculosis MmpL3 Increase Resistance to MmpL3 Inhibitors.
mSphere - 14 Oct 2020
McNeil Matthew B, O'Malley Theresa, Dennison Devon, Shelton Catherine D, Sunde Bjorn, Parish Tanya
Abstract excerpt
The Mycobacterium tuberculosis protein MmpL3 performs an essential role in cell wall synthesis, since it effects the transport of trehalose monomycolates across the inner membrane. Numerous structurally diverse pharmacophores have been identified as inhibitors of MmpL3 largely based on the identification of resistant isolates with mutations in MmpL3. For some compounds, it is possible there are different primary...
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