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Article

FLT3 inhibitors and novel therapeutic strategies to reverse AML resistance: An updated comprehensive review.

Critical reviews in oncology/hematology - 1 Nov 2023

Abdel-Aziz Amal Kamal, Dokla Eman M E, Saadeldin Mona Kamal

Abstract excerpt

FMS-like tyrosine kinase 3 (FLT3) mutations occur in almost 30% of acute myeloid leukemia (AML) patients. Despite the initial clinical efficacy of FLT3 inhibitors, many treated AML patients with mutated FLT3 eventually relapse. This review critically discusses the opportunities and challenges of FLT3-targeted therapies and sheds light on their drug interactions as well as potential biomarkers. Furthermore, we...

Topics

Humans
fms-Like Tyrosine Kinase 3
Leukemia, Myeloid, Acute
Drug Resistance, Neoplasm
Protein Kinase Inhibitors
Mutation
Antineoplastic Agents
Molecular Targeted Therapy
Animals

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37717880
DOI: 10.1016/j.critrevonc.2023.104139

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-37717880-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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