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New Pattern of Emerging Somatic Mutations in Optimal Responders Following Tyrosine Kinase Inhibitor Therapy in Chronic Myeloid Leukemia Patients

2025-11-05

Abstract excerpt

<title>Abstract</title> <p> Tyrosine kinase inhibitors (TKIs) significantly improved outcomes for patients with chronic myeloid leukemia (CML), enabling optimal treatment responses and near-normal life expectancy. Despite optimal responses, clonal evolution (CE) in Philadelphia chromosome-negative (Ph-negative) cells occurs in 10–15% of optimal responders, typically detected via cytogenetics. The mutational dyna...

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Literature Corpus work
47a90719-70fc-53ab-99aa-aa14e23f65ca
DOI
10.21203/rs.3.rs-7924728/v1
Open publication

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New Pattern of Emerging Somatic Mutations in Optimal Responders Following Tyrosine Kinase Inhibitor Therapy in Chronic Myeloid Leukemia PatientsDOI 10.21203/rs.3.rs-7924728/v1
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