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Article

Proton-sensing G-protein-coupled receptors.

Nature - 4 Sept 2003

Ludwig Marie-Gabrielle, Vanek Miroslava, Guerini Danilo, Gasser Jürg A, Jones Carol E, Junker Uwe, Hofstetter Hans, Wolf Romain M, Seuwen Klaus

Abstract excerpt

Blood pH is maintained in a narrow range around pH 7.4 mainly through regulation of respiration and renal acid extrusion. The molecular mechanisms involved in pH homeostasis are not completely understood. Here we show that ovarian cancer G-protein-coupled receptor 1 (OGR1), previously described as a receptor for sphingosylphosphorylcholine, acts as a proton-sensing receptor stimulating inositol phosphate...

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Identifiers

PMID: 12955148
DOI: 10.1038/nature01905

Genes

GPR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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