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Article

Expression profiles of proton-sensing G-protein coupled receptors in common skin tumors

18 Sept 2020

Abstract excerpt

Abstract The proton-sensing GPCRs (pH-GPCRs) GPR4 (GPR19), TDAG8 (GPR65, T-cell death associated gene 8), OGR1 (GPR68, ovarian cancer GPCR1), and G2A (GPR132, G2 accumulation protein) are involved in sensing and transducing changes in extracellular pH (pHe). Extracellular acidification is a central hallmark of solid cancer. pH-GPCR function has been associated with cancer cell proliferation, adhesion, migration...

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PMID: 32948783
DOI: 10.1038/s41598-020-71700-9

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