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Article

Crosslinking of Ly6a metabolically reprograms CD8 T cells for cancer immunotherapy

27 Sept 2024

Abstract excerpt

T cell inhibitory mechanisms prevent autoimmune reactions, while cancer immunotherapy aims to remove these inhibitory signals. Chronic ultraviolet (UV) exposure attenuates autoimmunity through promotion of poorly understood immune-suppressive mechanisms. Here we show that mice with subcutaneous melanoma are not responsive to anti-PD1 immunotherapy following chronic UV irradiation, given prior to tumor injection,...

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PMID: 39333093
DOI: 10.1038/s41467-024-52079-x

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